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5α-Tetrahydrocorticosterone

SKU: orb3136105

Description

5α-Tetrahydrocorticosterone (5α-HB) is an endogenous steroid that acts as an agonist of the glucocorticoid receptor (GR) and a metabolite of corticosterone. It serves as an effective topical anti-inflammatory agent in vivo. In rat liver cells, it decreases the binding of metabolites to the glucocorticoid receptor-corticosterone and its 5α-reduced metabolites, with a Kd value of 268 nM. 5α-Tetrahydrocorticosterone is applicable in research on inflammatory skin diseases.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number600-63-5
MW350.49
FormulaC21H34O4
SMILESC[C@@]12[C@@]3([C@]([C@]4([C@](C)(C[C@@H]3O)[C@@H](C(CO)=O)CC4)[H])(CC[C@]1(C[C@H](O)CC2)[H])[H])[H]
TargetEndogenous Metabolite,Glucocorticoid Receptor,Drug Metabolite

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information