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5J-4

SKU: orb1305391

Description

5J-4 is a potent and selective inhibitor of the CRAC channel, effectively suppressing store-operated calcium entry (SOCE). This action leads to reduced IL-17 production and downregulation of the transcription factors RORα and RORγt, making it a valuable tool for studying Th17 cell biology and related autoimmune pathologies in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number827001-82-1
MW312.34
Purity96.12% (May vary between batches)
FormulaC16H12N2O3S
SMILESOC1=CC=C2C(NC(=S)NC(=O)C3=CC=CO3)=CC=CC2=C1
TargetCalcium Channel
SolubilityDMSO:50 mg/mL (160.08 mM)

Bioactivity

In Vivo
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of the infiltrated mononuclear cell in the CNS, and significantly decreased the population of infiltrated CD4+ population. 5J-4 reduced the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in the mouse model of inflammation.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

5J 4, 5J4, 5J-4, Calcium release-activated channels, Calcium Channel, Ca2+ release-activated Ca2+ channels, CRAC channel, CRAC Channel, CNS, CD4+ cells, CalciumChannel, Inhibitor, inhibit, inflammation, mononuclear cell, experimental autoimmune encephalomyelitis
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 160.00
10 mg
$ 200.00
25 mg
$ 310.00
50 mg
$ 440.00
DispatchUsually dispatched within 3-5 working days
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