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6-Chloromelatonin

SKU: orb1704721

Description

6-Chloromelatonin is a metabolically stable melatonin receptor agonist with high affinity for MT2 receptors. It is utilized in sleep and depression research to study receptor function and neurotransmitter release, such as dopamine, in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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6-Chloromelatonin

Key Properties

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CAS Number63762-74-3
MW266.72
Purity97.26% (May vary between batches)
FormulaC13H15ClN2O2
SMILESC(CNC(C)=O)C=1C=2C(=CC(Cl)=C(OC)C2)NC1
TargetDopamine Receptor,Melatonin Receptor
SolubilityDMSO:90 mg/mL (337.43 mM)

Bioactivity

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Target IC50
MT1:8.9 (pKi)|MT2:9.1 (pKi)
In Vivo
6-Chloromelatonin (0.5 mg/kg; injection; rats) on the day after the phase shift has markedly higher excretion rates of 6-Sulphatoxymelatonin compared with controls.
In Vitro
6-Chloromelatonin (10 pM, 1 nM, 100 nM, 10 μM; 72 h) inhibits forskolin-stimulated hCG-beta secretion in JEG-3 and BeWo cells in a dose-dependent manner but had no effect on basal human chorionic gonadotrophin (hCG-beta) levels. 6-Chloromelatonin competes for [3H]-melatonin binding sites in human platelet (Ki=11.4 nM).

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Dopamine, Dopamine Receptor, DopamineReceptor, 6 Chloromelatonin, 6Chloromelatonin, 6-Chloromelatonin, Melatonin Receptor, MelatoninReceptor
Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
1858 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 390.00
5 mg
$ 870.00
10 mg
$ 1,170.00
25 mg
$ 1,630.00
50 mg
$ 2,020.00
100 mg
$ 2,540.00
500 mg
$ 4,940.00
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