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6PPD-Q

SKU: orb2278596

Description

6PPD-Quinone is a potent environmental pollutant and research chemical that acts as a high-affinity cannabinoid receptor 2 (CNR2) agonist. It is used to model male reproductive toxicity and neurointestinal pathology in vivo, studying mechanisms involving mitochondrial dysfunction, metabolic disruption, and protein aggregation.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2754428-18-5
MW298.38
Purity99.40% (May vary between batches)
FormulaC18H22N2O2
SMILESO=C1C=C(NC(C)CC(C)C)C(=O)C=C1NC=2C=CC=CC2
TargetEndogenous Metabolite
SolubilityDMSO:10 mg/mL (33.51 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
L02 cells:22.51 µg/L|HEK293 cells (10% FBS):11.78 μM|HEK293 cells (Albumin-free):3.84 μM|HEK293 cells (40 g/L HSA):23.96 μM|ERRγ:6 nM
In Vivo
METHODS: To study the effect of 6PPD-Q on intestinal injury, 6PPD-Q (0.1, 1, 10, 100 μg/kg) was orally administered to ICR mice once daily for 21 days. RESULTS: 6PPD-Q caused intestinal injury in ICR mice, which was manifested as enhanced inflammatory response in jejunum and ileum and impaired intestinal barrier integrity.
In Vitro
METHODS: Mouse dopaminergic neurons were treated with 6PPD-Q (10 nM, 100 nM) for 48 hours to detect cell growth inhibition. RESULTS: R6PPD-Q did not exhibit significant cytotoxicity. METHODS: Mouse dopaminergic neurons were treated with 6PPD-Q (10 nM, 100 nM) for 7 days, and target protein expression was detected by Western Blot. RESULTS: R6PPD-Q significantly increased Triton X-100-insoluble α-synuclein (α-syn) protein levels.

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

6PPD-Q, 6PPD-Quinone, Endogenous Metabolite, EndogenousMetabolite

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Key Properties

No computed properties available.

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6PPD-Q (orb2278596)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,300.00
5 mg
¥ 2,210.00
10 mg
¥ 2,990.00
25 mg
¥ 4,420.00
50 mg
¥ 6,500.00
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