7-FluorotryptaMine HCl

SKU: orb1819003

Description

7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	159730-09-3
MW	214.67
Purity	98.06%
Formula	C₁₀H₁₂ClFN₂
SMILES	Cl.FC1=CC=CC=2C(=CNC12)CCN
Target	GPCR,Arrestin
Solubility	DMSO:21.47 mg/mL (100.01 mM)

Bioactivity

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In Vitro	In the PRESTO-Tango assay, 7-FluorotryptaMine HCl (100 μM) hydrochloride induces GPRC5A recruitment of β-arrestin. Co-treatment with 7-FluorotryptaMine HCl (50 μM, 8 h) and TNFα downregulates TNFα-induced genes (e.g., IL41A, CXCL10, CSF2) in WT and GPRC5A-KO cells . 7-FluorotryptaMine HCl (0-100 μM, 16 h) is not toxic to mammalian cells (HTLA, HT-29 cells). Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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7FluorotryptaMineHCl, 7-FluorotryptaMine HCl, GPRC5A

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Compound Identifiers

PubChem CID

53487481 ↗

Key Properties

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No computed properties available.

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