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7-Methoxyrosmanol

SKU: orb1297478

Description

7-Methoxyrosmanol

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number113085-62-4
MW360.44
Purity98.40% (May vary between batches)
FormulaC21H28O5
SMILES[H][C@@]12[C@@H]3OC(=O)[C@@]1(CCCC2(C)C)c1c(O)c(O)c(cc1[C@@H]3OC)C(C)C
TargetcAMP
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.55 mM);DMSO:12 mg/mL (33.29 mM)

Bioactivity

In Vitro
In order to find new effective HIV protease inhibitors, two diterpenes (carnosic acid and carnosol) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol and semisynthetic derivatives (7-Methoxyrosmanol 7-O-ethylrosmanol, and 11,12-O,O-dimethylcarnosol) were prepared. The inhibitory activity of all six compounds against HIV-1 protease was tested. The carnosic acid showed the strongest inhibitory effect (IC90 = 0.08 micrograms/ml). The same compound was also assayed against HIV-1 virus replication (IC90 = 0.32 micrograms/ml).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, cAMP, 7 Methoxyrosmanol, 7-O-Methylrosmanol, 7Methoxyrosmanol, 7-Methoxyrosmanol
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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 160.00
5 mg
$ 330.00
1 ml x 10 mM (in DMSO)
$ 360.00
10 mg
$ 470.00
25 mg
$ 740.00
50 mg
$ 1,010.00
DispatchUsually dispatched within 3-5 working days
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