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7,4'-Dimethoxy-3-hydroxyflavone

SKU: orb3135023

Description

7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. This compound inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 μM. It disrupts PAR4-mediated aggregation and related signaling pathways, including NF-κB, Ca2+/protein kinase C (PKC), Akt, ERK, and p38. In a streptozotocin (STZ)-induced diabetic mouse model, 7,4'-Dimethoxy-3-hydroxyflavone inhibits vascular PAR4 expression, improves endothelial dysfunction, and reduces oxidative stress. Additionally, it prevents thrombosis in mice without affecting bleeding time.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number13198-99-7
MW298.29
FormulaC17H14O5
SMILESO=C1C(O)=C(OC2=CC(OC)=CC=C21)C=3C=CC(OC)=CC3
TargetAkt,ROS,Protease-activated Receptor,p38 MAPK,ERK,NF-κB,Calcium Channel,PKC

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information