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A-582941 dihydrochloride

SKU: orb1306121

Description

A-582941 dihydrochloride is a selective partial agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR). This compound is utilized in neuroscience research to investigate receptor function and has been applied in both in vitro and in vivo studies exploring cognitive processes and neuropsychiatric disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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A-582941 dihydrochloride

Key Properties

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CAS Number848591-90-2
MW353.29
Purity99.55% (May vary between batches)
FormulaC17H22Cl2N4
SMILESCN(CC1C2)CC1CN2C3=NN=C(C4=CC=CC=C4)C=C3.Cl.Cl
TargetAChR,5-HT Receptor
SolubilityDMSO:55 mg/mL (155.68 mM)

Bioactivity

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Target IC50
5-HT3 receptor:150 nM (Ki)|α7 nAChR:10.8 nM (Ki, for rat α7 receptors)|α7 nAChR:16.7 nM (Ki, for human α7 receptors)
In Vivo
A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs. In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation. A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit. A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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deficits, cognitive, 5-HT3, A 582941, 5-HT Receptor, 5HT Receptor, A582941, A-582941, A-582941 Dihydrochloride, 5HTReceptor, partial, neurodegenerative, nAChR, α7 nAChR
Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
67162119 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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2 mg
$ 70.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 190.00
50 mg
$ 270.00
100 mg
$ 380.00
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