A 77636 hydrochloride

SKU: orb1306202

Description

A 77636 hydrochloride is a potent, selective, and orally bioavailable dopamine D1 receptor agonist (Ki=39.8 nM) with demonstrated antiparkinsonian effects in vivo. It exhibits no functional activity at D2 receptors, making it a valuable research tool for studying D1-mediated neurobiology and Parkinson's disease models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	145307-34-2
MW	365.89
Purity	99.57%
Formula	C₂₀H₂₈ClNO₃
SMILES	Cl.NCC1OC(Cc2c(O)c(O)ccc12)C12CC3CC(CC(C3)C1)C2
Target	Dopamine Receptor
Solubility	DMSO:3.66 mg/mL (10 mM);H2O:soluble

Bioactivity

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In Vivo	A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake in male hooded rat, due principally to a reduction in meal size and duration.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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A77636 Hydrochloride, A77636 hydrochloride, A-77636 Hydrochloride, A 77636 Hydrochloride, DopamineReceptor, Dopamine Receptor, D1

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Compound Identifiers

PubChem CID

16069211 ↗

Key Properties

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No computed properties available.

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