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Aβ42 agonist-1

SKU: orb2566887

Description

Aβ42 agonist-1 is a small molecule research compound that promotes Aβ42 aggregation and inhibits NF-κB signaling. It is utilized in vitro and in vivo for studying cancer mechanisms and neurological disorders, including Alzheimer's disease research.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number50635-12-6
MW237.25
Purity99.77% (May vary between batches)
FormulaC15H11NO2
SMILESO=C(NC=1C=CC=CC1)C=2OC=3C=CC=CC3C2
TargetGamma-secretase,Beta Amyloid
SolubilityDMSO:100 mg/mL (421.5 mM)

Bioactivity

In Vitro
Aβ42 agonist-1 can promote and accelerate Aβ42 aggregation, is non-toxic to HT22 hippocampal neurons, and compared with Aβ42 treatment group (cell viability ~ 20%), It can significantly prevent the cytotoxicity (cell viability ~ 74%) of HT22 hippocampal neuron cells induced by Aβ42.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 80.00
5 mg
$ 130.00
10 mg
$ 170.00
25 mg
$ 310.00
50 mg
$ 440.00
100 mg
$ 620.00
200 mg
$ 860.00
DispatchUsually dispatched within 5-10 working days
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