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Aβ42 agonist-1

SKU: orb2566887

Description

Aβ42 agonist-1 is a small molecule research compound that promotes Aβ42 aggregation and inhibits NF-κB signaling. It is utilized in vitro and in vivo for studying cancer mechanisms and neurological disorders, including Alzheimer's disease research.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number50635-12-6
MW237.25
Purity99.77%
FormulaC15H11NO2
SMILESO=C(NC=1C=CC=CC1)C=2OC=3C=CC=CC3C2
TargetGamma-secretase,Beta Amyloid
SolubilityDMSO:100 mg/mL (421.5 mM)

Bioactivity

In Vitro
Aβ42 agonist-1 can promote and accelerate Aβ42 aggregation, is non-toxic to HT22 hippocampal neurons, and compared with Aβ42 treatment group (cell viability ~ 20%), It can significantly prevent the cytotoxicity (cell viability ~ 74%) of HT22 hippocampal neuron cells induced by Aβ42.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Aβ42 agonist-1 (orb2566887)

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Available Sizes

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1 mg
¥ 1,040.00
5 mg
¥ 1,690.00
10 mg
¥ 2,210.00
25 mg
¥ 4,030.00
50 mg
¥ 5,720.00
100 mg
¥ 8,060.00
200 mg
¥ 11,180.00
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