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Abrocitinib

SKU: orb1296253

Description

Abrocitinib

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1622902-68-4
MW323.41
Purity99.91%
FormulaC14H21N5O2S
SMILESCCCS(=O)(=O)N[C@H]1C[C@H](C1)N(C)c1ncnc2[nH]ccc12
TargetJAK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.37 mM);DMSO:125 mg/mL (386.51 mM)

Bioactivity

Target IC50
JAK1:29 nM|JAK2:803 nM|TYK2:1253 nM
In Vivo
In the rat adjuvant-induced arthritis model, Abrocitinib (5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling.
In Vitro
Abrocitinib inhibits IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), IFNα-stimulated phosphorylation of STAT3, as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 163, 189 nM, 7.178 μM, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PF04965842, PF-04965842, PF 04965842, inhibit, JAK1, JAK2, JAK, Janus kinase, Inhibitor, Abrocitinib

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Key Properties

No computed properties available.

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Abrocitinib (orb1296253)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
10 mg
¥ 1,820.00
25 mg
¥ 3,640.00
50 mg
¥ 5,980.00
100 mg
¥ 10,400.00
DispatchUsually dispatched within 3-5 working days
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