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AC-099 hydrochloride

SKU: orb1941559

Description

AC-099 hydrochloride is a small molecule acting as a selective, full agonist at the NPFF2 receptor (EC50=1189 nM) and a partial agonist at NPFF1R (EC50=2370 nM). It is applied in research to reverse opioid-induced hyperalgesia and is utilized in both in vitro receptor studies and in vivo models of nociceptive sensitization and opioid tolerance.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number849335-07-5
MW301.1
Purity99.86% (May vary between batches)
FormulaC9H9Cl2F3N4
SMILESCl.FC(F)(F)C1=CC(C=NNC(=N)N)=CC=C1Cl
TargetNeuropeptide FF Receptor,Others

Bioactivity

In Vivo
The NPFF2 agonist AC-099 (30 mg/kg; i.p.) exhibits activity in various pain models in vivo, whereas non-selective NPFF1 agonist administration increases sensitivity to both noxious and non-noxious stimuli.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Neuropeptide Y Receptor, NeuropeptideYReceptor, NPFFR2
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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 110.00
25 mg
$ 140.00
50 mg
$ 170.00
100 mg
$ 250.00
DispatchUsually dispatched over 10 weeks
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