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AC-262536

SKU: orb1305214

Description

AC-262536 is a potent and selective androgen receptor modulator (SARM) with partial agonist activity relative to testosterone. It demonstrates luteinizing hormone suppression and is utilized in research exploring muscle wasting, osteoporosis, and androgen receptor pharmacology in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

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AC-262536

Key Properties

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CAS Number870888-46-3
MW278.35
Purity99.38% (May vary between batches)
FormulaC18H18N2O
SMILESO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc(C#N)c2ccccc12
TargetAndrogen Receptor
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (3.59 mM);DMSO:50 mg/mL (179.63 mM)

Bioactivity

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In Vivo
In male sprague-dawley rats, administration of AC-262536 (subcutaneous injection, once daily for 14 consecutive days) significantly decreased LH levels by about 40% at the 3 mg/kg dose. At the 10 and 30 mg/kg doses, the effects of AC-262536 were significantly stronger than Testosterone Propionate (TP) : 1.91±0.32 ng/mL and 1.53±0.34 ng/mL vs. 3.12±0.69 ng/mL, respectively.
In Vitro
AC-262536 inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP in a dose-dependent manner. The effects are significant with 100 nM, and reaches a plateau with 1 μM.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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SARM, receptor, Inhibitor, non-steroidal, inhibit, modulator, AC 262536, AC262536, AC-262536, anabolic, androgen, AndrogenReceptor, Androgen Receptor
Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
44512434 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 90.00
25 mg
$ 130.00
50 mg
$ 200.00
100 mg
$ 270.00
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