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AC1NS4RE

SKU: orb1223442

Description

SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21.

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Key Properties

CAS Number1055412-47-9
MW272.73
Purity>98% (HPLC)
FormulaC15H13ClN2O
SMILESCc1cc(c([nH]1)/C=C\1/c2c(ccc(c2)Cl)NC1=O)C
TargetOthers
SolubilityIn Vitro: DMSO : 16.67 mg/mL (61.12 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SU5614 | SU 5614 | SU5614

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  • AC1NS4RE [orb1305640]

    99.53% (May vary between batches)

    1055412-47-9

    272.73

    C15H13ClN2O

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 2 mg
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AC1NS4RE (orb1223442)

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Available Sizes

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200 mg
500 mg
2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
10 mg
¥ 1,690.00
25 mg
¥ 2,990.00
50 mg
¥ 4,940.00
100 mg
¥ 8,450.00