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Acetylene-linker-Val-Cit-PABC-MMAE

SKU: orb1988832

Description

LCB14-0602 is a cleavable drug-linker conjugate designed for constructing antibody-drug conjugates (ADCs). It features the valine-citrulline (Val-Cit) dipeptide linked to the cytotoxic payload monomethyl auristatin E (MMAE) via a self-immolative PABC spacer. This construct is widely used in ADC research for targeted cancer therapy, enabling the selective release of MMAE in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number1411977-95-1
MW1307.62
FormulaC67H106N10O16
SMILESCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)COCCOCCOCC#C)C(C)C)cc1)C(C)C
TargetDrug-Linker Conjugates for ADC

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information

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100 mg
$ 2,170.00
DispatchUsually dispatched within 5-10 working days
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