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ACP-105

SKU: orb1308694

Description

ACP-105 is a potent, nonsteroidal selective androgen receptor modulator (SARM) exhibiting partial agonist activity compared to testosterone. It is utilized in preclinical research to study androgen receptor function in models of muscle wasting, osteoporosis, and hormone-related cancers.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number899821-23-9
MW290.79
Purity99.53% (May vary between batches)
FormulaC16H19ClN2O
SMILESCc1c(Cl)c(ccc1N1[C@H]2CC[C@@H]1C[C@](C)(O)C2)C#N
TargetAndrogen Receptor
SolubilityEthanol:60 mg/mL (206.33 mM);DMSO:60 mg/mL (206.33 mM)

Bioactivity

Target IC50
AR (T877A):9.3 (pEC50)|AR (WT):9.0 (pEC50)
In Vivo
Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. There are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance.
In Vitro
ACP-105 is an orally administered, selective, and potent androgen receptor modulator (SARM), demonstrating high affinity with pEC50 values of 9.0 and 9.3 for the AR wild type and T877A mutant, respectively. In human hepatocytes, the half-life of ACP-105 (compound 1) is determined to be 5.0 hours.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Androgen Receptor, AndrogenReceptor, AR T877A mutant, AR wild type, ACP105, ACP-105, ACP 105, inhibit, Inhibitor

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    899821-23-9

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    C16H19ClN2O

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 100.00
5 mg
$ 100.00
10 mg
$ 130.00
25 mg
$ 210.00
50 mg
$ 280.00
100 mg
$ 390.00
200 mg
$ 520.00
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