ADDA 5 hydrochloride

SKU: orb1707713

Description

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	473268-46-1
MW	406
Formula	C₂₄H₃₆ClNO₂
SMILES	Cl.OC(COCCC12CC3CC(CC(C3)C1)C2)CN4CC=5C=CC=CC5CC4
Target	Cytochromes P450,Others
Solubility	H2O:1 mg/mL (2.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.93 mM);DMSO:50 mg/mL (123.15 mM)

Bioactivity

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Target IC50	CcO (human glioma):18.93 μM\|CcO (bovine heart):31.82 μM
In Vivo	Method: ADDA 5 was administered intraperitoneally (i.p.) at a dose of 8 mg/kg to tumor-bearing mice to evaluate its antitumor efficacy and in vivo toxicity. Result: ADDA 5 (8 mg/kg, i.p.) significantly inhibited tumor growth in mice, and no detectable toxicity was observed at doses up to 80 mg/kg. Read more...
In Vitro	Method: ADDA 5 hydrochloride was used to treat cytochrome c oxidase (CcO) purified from human glioma cells and bovine heart, as well as glioblastoma stem cell (GSC) lines derived from UTMZ and Jx22, to evaluate its inhibitory effects on CcO activity and cell proliferation. Result: ADDA 5 hydrochloride partially and non-competitively inhibited CcO from human glioma and bovine heart, with IC₅₀ values of 18.93 μM and 31.82 μM, respectively. It also inhibited CcO activity in UTMZ and Jx22 GSCs, with IC₅₀ values of 21.4 μM and 15.5 μM, and exhibited antiproliferative effects on UTMZ cells (EC₅₀ = 8.17 μM). Read more...

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CcO, bovine heart, CcO, human glioma, ADDA 5 Hydrochloride, ADDA 5 hydrochloride, ADDA5 hydrochloride, ADDA-5 Hydrochloride

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Compound Identifiers

PubChem CID

2882960 ↗

Key Properties

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No computed properties available.

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