AKN-028

SKU: orb1303656

Description

AKN-028 is a potent and orally bioavailable small molecule inhibitor of FLT3 tyrosine kinase, demonstrating an IC50 of 6 nM. It effectively suppresses FLT3 autophosphorylation in a dose-dependent manner and is utilized in preclinical research for investigating acute myeloid leukemia (AML) in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1175017-90-9
MW	302.33
Purity	99.88% (May vary between batches)
Formula	C₁₇H₁₄N₆
SMILES	N(C=1N=C(C=NC1N)C=2C=CN=CC2)C=3C=C4C(=CC3)NC=C4
Target	Apoptosis,Caspase,FLT
Solubility	DMSO:20 mg/mL (66.15 mM)

Bioactivity

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Target IC50	FLT3:6 nM (IC50)\|CLK1:140 nM (IC50)\|RPS6KA:220 nM (IC50)\|FGFR2:1200 nM (IC50)\|VEGFR2:520 nM (IC50)
In Vivo	AKN-028 (15 mg/kg, Subcutaneously injection twice daily) exhibits anti-tumor activities for acute myeloid leukemia (AML) models . Animal Model: Mice based AML and MV4-11 cells . Dosage: 15 mg/kg. Administration: Subcutaneously injection twice daily. Result: Inhibited net growth of one of the primary AML samples (UPN26) in vivo and furthermore reduced the tumor mass of MV4-11 cell line. Read more...
In Vitro	AKN-028 triggers apoptosis in MV4-11 by activation of caspase 3 . AKN-028 (10 μM) is cytotoxic to AML cell lines and induces apoptosis in the AML cell line MV4-11 . Cell Cytotoxicity Assay Cell Line: AML cell line MV4-11. Concentration: 10 μM. Incubation Time: 24 h. Result: Was cytotoxic to primary AML cells, irrespective of FLT3 mutation status and quantitative FLT3 expression. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Fms like tyrosine kinase 3, FLT3 autophosphorylation, FLT3, inhibit, Inhibitor, CD135, Cluster of differentiation antigen 135, cytotoxic, Apoptosis, AML cell lines, Caspase, AKN 028, AKN028, AKN-028, acute myeloid leukemia

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Compound Identifiers

PubChem CID

44177328 ↗

Key Properties

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No computed properties available.

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AKN-028 (orb1303656)

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MW:	362.39
Formula:	C₁₉H₁₈N₆O₂

CAS Number:	1175017-91-0
MW:	416.36
Formula:	C₁₉H₁₅F₃N₆O₂

AKN-028

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

AKN-028 acetate [orb1688679]

AKN-028 trifluoroacetate [orb1698605]

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AKN-028 (orb1303656)

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