Alarelin Acetate

SKU: orb1308462

Description

Alarelin Acetate is a synthetic GnRH agonist that binds to GnRH receptors to directly suppress rat GSMC proliferation and DNA synthesis. This mechanism supports its use in researching hormone-responsive systems, including in vitro cell studies and in vivo models for reproductive biology and oncology.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	79561-22-1
MW	1167.34
Purity	99.81%
Formula	C₅₆H₇₈N₁₆O₁₂
SMILES	CC(O)=O.CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1
Target	GNRH Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.71 mM);DMSO:58 mg/mL (49.69 mM)

Bioactivity

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In Vivo	Alarelin effectively suppresses gastric acid secretion in rats through direct interaction with parietal cells and by impairing vagal function . Additionally, Alarelin significantly elevates the ratio of G1 phase while reducing the S phase ratio in rat gastric smooth muscle cells (GSMC) . Read more...
In Vitro	Cell viability significantly decreased when exposed to alarelin, as compared to its absence. The peak stimulatory effect on cell viability occurred at a concentration of 10^-5 M, with alarelin demonstrating dose-dependent activity. Read more...
Cell Research	The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader. Read more...

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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GNRH Receptor, GNRHReceptor, GnRHR, Alarelin, Alarelin Acetate

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Compound Identifiers

PubChem CID

12821051 ↗

Key Properties

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No computed properties available.

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