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ALLO-2

SKU: orb1308672

Description

ALLO-2 is a potent inhibitor of drug-resistant Smoothened (Smo) mutants. It effectively blocks Hh-Ag1.5-induced Hedgehog pathway activity in TM3-Gli-Luc reporter cells with an IC50 of 6 nM, making it a valuable tool for investigating Smo-dependent signaling in cancer research and drug resistance studies both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1357350-60-7
MW371.32
Purity98.67% (May vary between batches)
FormulaC18H12F3N5O
SMILESFC(F)(F)Oc1ccc(cc1)-c1ccnc(Nc2ccc3[nH]ncc3c2)n1
TargetHedgehog/Smoothened,Smo
SolubilityDMSO:125 mg/mL (336.64 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.77 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Smoothened, Smo, ALLO2, ALLO-2, ALLO 2, Hedgehog, Inhibitor, inhibit

Similar Products

  • ALLO-2 [orb1219380]

    >98% (HPLC)

    1357350-60-7

    371.32

    C18H12F3N5O

    5 mg, 10 mg, 25 mg, 100 mg, 50 mg, 2 mg, 500 mg, 1 g
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 190.00
1 ml x 10 mM (in DMSO)
$ 200.00
10 mg
$ 270.00
25 mg
$ 420.00
50 mg
$ 570.00
100 mg
$ 740.00
200 mg
$ 1,000.00
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