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AM-1638

SKU: orb1707679

Description

AM-1638 is a potent and orally bioavailable agonist of the GPR40 (FFA1) receptor. It serves as a valuable research tool for investigating the role of this receptor in glucose homeostasis and insulin secretion, with applications in both in vitro and in vivo models of type 2 diabetes.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1142214-62-7
MW514.63
Purity99.97%
FormulaC33H35FO4
SMILESFC=1C(C2=C(C=C(COC3=CC([C@@H](CC(O)=O)[C@@H]4CC4)=CC=C3)C=C2)C=5C(C)(C)CCC5)=CC(OC)=CC1
TargetGPCR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.41 mM);DMSO:80 mg/mL (155.45 mM)

Bioactivity

Target IC50
FFA1/GPR40:0.16 μM
In Vivo
Methods: AM-1638 (1 mg/kg, IV) and (5 mg/kg, oral) were administered to mice; AM-1638 (0.5 mg/kg, IV) and (2 mg/kg, oral) were administered to rats; and AM-1638 (0.5 mg/kg, IV) and (2 mg/kg, oral) were administered to cynomolgus monkeys for pharmacokinetic studies. Results: Oral administration of AM-1638 showed excellent oral bioavailability (mice, >100%; rats, 72%; cynomolgus monkeys, 71%); and showed antidiabetic activity in BDF/DIO mice.

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AM 1638, AM1638, AM-1638, GPR40/FFA1
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

AM-1638 (orb1707679)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 2,470.00
5 mg
¥ 3,770.00
1 ml x 10 mM (in DMSO)
¥ 4,160.00
10 mg
¥ 5,720.00
25 mg
¥ 10,920.00
50 mg
¥ 15,600.00
100 mg
¥ 23,010.00
DispatchUsually dispatched within 5-10 working days
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