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AM580

SKU: orb1220663

Description

AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )

Images & Validation

Key Properties

CAS Number102121-60-8
MW351.44
Purity>98% (HPLC)
FormulaC22H25NO3
SMILESCC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc1ccc(cc1)C(O)=O
TargetRetinoid Receptor
SolubilityDMSO:45 mg/mL (128.04 mM)

Bioactivity

In Vitro
AM580 (GMP) (0.05 μM) induces mouse embryonic fibroblasts (MEFs) convert into chemically induced pluripotent stem cells (CiPSCs) with the adding in stage I and stage II medium. AM580 (GMP) (0-10 μM; 4 d) induces SH-SY5Y cells develop into neuron-like cells. AM580 (GMP) shows powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 (GMP) (2.5 μM; 4 d) induces myeloid progenitors develop into neutrophils.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CD336 | NSC608001 | Ro 40-6055

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  • AM-580 [orb1301429]

    >98%

    102121-60-8

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    C22H25NO3

    5 mg, 25 mg
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Protocol Information

Available Sizes

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2 mg
$ 70.00
5 mg
$ 100.00
10 mg
$ 140.00
25 mg
$ 280.00
50 mg
$ 530.00
100 mg
$ 770.00
500 mg
$ 1,730.00