Amitifadine hydrochloride

SKU: orb1705330

Description

Amitifadine hydrochloride (EB-1010 hydrochloride) is a small molecule triple reuptake inhibitor (SNDRI) that blocks the transporters for serotonin, norepinephrine, and dopamine. It is used in preclinical research to investigate the mechanisms and potential therapeutic applications of multi-target antidepressants in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	410074-74-7
MW	264.58
Formula	C₁₁H₁₂Cl₃N
SMILES	Cl.Clc1ccc(cc1Cl)[C@@]12C[C@@H]1CNC2
Target	Norepinephrine,5-HT Receptor,Serotonin Transporter,Dopamine Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.56 mM);DMSO:10 mM

Bioactivity

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Target IC50	Dopamine (HEK293 cells):96 nM\|Norepinephrine (HEK293 cells):23 nM\|5-HT (HEK293 cells):12 nM

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SLC6A3, SLC6A4, Serotonin Transporter, SerotoninTransporter, SERT, 5HT Receptor, 5HTReceptor, 5-HTT, 5-HT, Amitifadine, Amitifadine hydrochloride, Amitifadine Hydrochloride, DAT, Dopamine, EB 1010, EB 1010 Hydrochloride, EB1010, EB-1010, EB1010 Hydrochloride, EB-1010 Hydrochloride, EB-1010 hydrochloride, Dopamine Receptor, Dopamine Transporter, DopamineReceptor, DOV21947, DOV-21947, DOV21947 Hydrochloride, DOV-21947 hydrochloride, DOV-21947 Hydrochloride, DOV 21947 Hydrochloride, DOV 21947, Norepinephrine (NE), Inhibitor, inhibit

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Compound Identifiers

PubChem CID

11680542 ↗

Key Properties

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No computed properties available.

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