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AMN082

SKU: orb1704920

Description

AMN082 is a selective mGluR7 receptor agonist used in neuroscience research. It exhibits neuroprotective properties against apoptosis in rodent TBI models and reduces behavioral sensitization to cocaine and morphine in vivo. This compound is a valuable tool for studying addiction, neuroprotection, and mood-related disorders in both in vitro and in vivo experimental systems.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number97075-46-2
MW465.46
Purity98.63%
FormulaC28H30Cl2N2
SMILESC1(C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4)=CC=CC=C1.Cl.Cl
TargetGluR
SolubilityDMSO:20 mg/mL (42.97 mM)

Bioactivity

In Vivo
Pretreatment of animals with the lower doses of AMN082 (1.25 5.0 mg/kg, i.p.), 30 min before every cocaine or morphine injection during repeated drug administration or before cocaine or morphine challenge, dose-dependently attenuated the development, as well as the expression of cocaine or morphine locomotor sensitization.
In Vitro
AMN082 inhibited 4-aminopyridine-evoked glutamate release and this phenomenon was blocked by the metabotropic glutamate mGlu7 receptor antagonist MMPIP. The effect of AMN082 on the 4-aminopyridine-evoked release of glutamate was prevented by chelating the extracellular Ca2+ ions and the vesicular transporter inhibitor.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AMN-082 Dihydrochloride, AMN082 Dihydrochloride, AMN 082 dihydrochloride, GRN-529, GRN 529, GRN529, mGluR7

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

AMN082 (orb1704920)

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Available Sizes

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1 mg
¥ 1,040.00
5 mg
¥ 1,560.00
10 mg
¥ 2,080.00
25 mg
¥ 3,510.00
DispatchUsually dispatched within 5-10 working days
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