Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

Anatibant 2HCl

SKU: orb1819277

Description

Anatibant 2HCl is a selective bradykinin B2 receptor antagonist used in neuroscience research. It is applied in both in vitro binding assays and in vivo models to study its potential neuroprotective effects in conditions such as traumatic brain injury and stroke.

Research Area

Pharmacology & Drug Discovery

Images & Validation

−
Anatibant 2HCl

Key Properties

−
CAS Number209788-45-4
MW784.58
Purity99.17% (May vary between batches)
FormulaC34H36Cl2N6O5S.2ClH
SMILESClC(C(S(=O)(N1[C@@H](CCC1)C(NCCCNC(C2=CC=C(C=C2)C(N)=N)=O)=O)=O)=CC=C3Cl)=C3COC4=CC=CC5=C4N=C(C)C=C5C.Cl.Cl
TargetBradykinin Receptor
SolubilityDMSO:55 mg/mL (70.1 mM)

Bioactivity

−
Target IC50
Bradykinin receptor B2:1.74 nM (Ki, rat recombinant B2 receptor)|Bradykinin receptor B2:1.37 nM (Ki, guinea-pig recombinant B2 receptor)|Bradykinin receptor B2:0.67 nM (Ki, human recombinant B2 receptor)
In Vivo
Anatibant (3.0 mg/kg b.w.; Subcutaneous Injection; Male C57/Bl6 mice (CCI)) was administrated as a subcutaneous bolus 15 min and 8h after TBI. ICP was measured 3, 6, and 10 h after injury, and contusion volume was quantified 24 h after trauma. Our data demonstrate a significant reduction of ICP (16.6+/-1.67 mmHg vs. 24.40+/-3.58 mmHg; n=6; p=0.002) and of contusion volume 24 h after trauma (28.28+/-5.18 mm3 vs. 35.0+/-3.32 mm3 n=7; p=0.003) in treated mice. Therefore we conclude, that inhibition of bradykinin B2 receptors seems to be a promising treatment option, and might therefore be investigated in clinical trials for the treatment of TBI.

Storage & Handling

−
Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
Anatibant, Anatibant 2HCl, Anatibant 2HCl(209733-45-9 Free base), bradykinin B2, Bradykinin Receptor, BradykininReceptor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
21968582 ↗

Key Properties

−
No computed properties available.

Protocol Information

Find More Protocols

Available Sizes

Select a size below

1 mg
$ 390.00
5 mg
$ 870.00
10 mg
$ 1,130.00
25 mg
$ 1,630.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

[email protected]

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor