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Angiotensin IV

SKU: orb1220538

Description

Angiotensin IV is a less effective agonist at the angiotensin AT1 receptor.

Research Area

Cardiovascular Research

Images & Validation

Key Properties

CAS Number12676-15-2
MW774.91
Purity>98% (HPLC)
FormulaC40H54N8O8
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
TargetRAAS

Bioactivity

In Vivo
Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Angiotensin II (3-8) human?

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Protocol Information

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