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ANGIOTENSIN IV TFA(12676-15-2(free base))

SKU: orb1299545

Description

Angiotensin IV TFA is a peptide analog that acts as a partial agonist with lower potency at the AT1 receptor compared to Angiotensin II. It is utilized in cardiovascular and renal research to study receptor subtype function and signaling pathways in both cellular and animal models.

Research Area

Cardiovascular Research; Immunology & Inflammation, Metabolism Research

Images & Validation

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ANGIOTENSIN IV TFA(12676-15-2(free base))

Key Properties

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MW888.92
Purity≥98% (May vary between batches)
FormulaC42H55F3N8O10
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)C(F)(F)F
TargetRAAS
SolubilityDMSO:25 mg/mL (28.12 mM)

Bioactivity

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In Vivo
Rats with CCH exhibited higher levels of Aβ42, p-tau and pro-inflammatory cytokines in the brain when compared with controls. Infusion of Ang IV significantly reduced the expression of pro-inflammatory cytokines in the brains of rats with CCH. Meanwhile, the reduction of pro-inflammatory cytokines levels caused by Ang IV was reversed by divalinal-Ang IV. During the treatment, the SBP in rats was not significantly altered
Animal Research
Eight weeks after bilateral CCA ligation surgery, rats were anaesthetized with 10% chloral hydrate and placed in a stereotactic frame. The scalp was reflected under sterile surgical conditions. A brain-infusion cannula coupled via vinyl tubing to an osmotic pump was implanted into the third cerebral ventricle by surgeons who were blinded to the experimental groups. Osmotic pumps were placed subcutaneously between the scapulae and used to infuse two doses of Ang IV (20 nM, 0.15 μl/h and 100 nM, 0.15 μl/h), divalinal-Ang IV (500 nM, 0.15 μl/h) or aCSF (0.15 μl/h) into the third cerebral ventricle, lasting for six weeks. Following this surgery, the wounds were carefully closed with sutures

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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ANGIOTENSIN IV TFA(12676 15 2(free base)), ANGIOTENSIN IV TFA(12676152(free base)), ANGIOTENSIN IV TFA(12676-15-2(free base)), angiotensin AT1 receptor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
134814482 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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2 mg
$ 80.00
5 mg
$ 100.00
10 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 150.00
25 mg
$ 220.00
50 mg
$ 300.00
100 mg
$ 420.00
200 mg
$ 580.00
DispatchUsually dispatched within 3-5 working days
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