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Anle138b-F105

SKU: orb2646117

Description

Anle138b-F105 is a potent AUTOTAC (autophagy-targeting chimera) with a DC50 of 3 nM, inducing lysosomal degradation of the tauP301L mutant. This small molecule facilitates the study of targeted protein degradation in models of tauopathy, applicable in both cellular and in vivo research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2941386-44-1
MW624.7
FormulaC36H37FN4O5
SMILESFC1=CC=C(C=C1)COC2=CC=CC(=C2)CNCCOCCOCCNC3=CC=CC(=C3)C4=CC(=NN4)C=5C=CC=6OCOC6C5
TargetAUTACs,Autophagy

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information