CD79b Antibody (MMAE)

SKU: orb1805469

Description

Anti-CD79b Reference Antibodyected antibody and Monomethyl auristatin E (MMAE) that can be used in combination with bendamustine and rituximab for the treatment of adult patients with at least two relapses or refractory diffuse large B-cell lymphoma. Polatuzumab vedotin binds to CD79b and is internalized by tumor cells. MMAE is cleaved from cells by lysosomal protease and promotes tumor cell apoptosis by inhibiting microtubule formation.

Images & Validation

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Tested Applications	ELISA, FA, FACS, In vivo
Reactivity	Human

Key Properties

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Antibody Type	Recombinant Antibody
Clonality	Recombinant
Target	CD79b
Source/Expression System	CHO
Molecular Weight	150.53 kDa
Purity	>95%
Purification	Protein A
Endotoxin	<0.001 EU/ug
Conjugation	MMAE

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	100 mM Proline/Acetic acid 20mM Arginine pH 5.0
Concentration	Batch dependent
Disclaimer	For research use only

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Anti-CD79b Reference Antibody (polatuzumab vedotin-piiq) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

The purity of Anti-CD79b Reference Antibody (polatuzumab vedotin-piiq)is more than 95% ;determined by SEC-HPLC.

Immobilized human CD79b; His Tag at 2 μg/mL can bind Anti-CD79b Reference Antibody (polatuzumab vedotin-piiq);EC50=0.005029μg/mL.

Quick Database Links

Gene Symbol

CD79b

UniProt

P40259

UniProt Details

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No UniProt data available

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Protocol Information

FACS

Fluorescence-Activated Cell Sorting (FC, Flow cytometry)

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ELISA

Enzyme-linked Immunosorbent Assay (EIA)

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