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CTLA-4/CD152 Antibody
SKU: orb1806363
Description
Images & Validation
−Item 1 of 4
| Tested Applications | ELISA, FA, FACS, In vivo |
|---|---|
| Reactivity | Human, Monkey |
Key Properties
−| Clonality | Monoclonal |
|---|---|
| Target | CTLA-4 / CD152 |
| Source/Expression System | CHO |
| Molecular Weight | 145.38 kDa |
| Purity | >95% |
| Purification | Protein A |
| Endotoxin | <0.001 EU/ug |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| Buffer/Preservatives | 100 mM Proline/Acetic acid 20mM Arginine pH 5.0 |
| Concentration | Batch dependent |
| Disclaimer | For research use only |
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Quality Guarantee
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Anti-CTLA-4 / CD152 Reference Antibody (ipilimumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
The purity of Anti-CTLA-4 / CD152 Reference Antibody (ipilimumab)is more than 99.37% ;determined by SEC-HPLC.
Human CTLA-4 & Human PD-1 CHO-K cells were stained with Anti-CTLA-4 / CD152 Reference Antibody (ipilimumab) and negative control protein respectively; washed and then followed by PE and analyzed with FACS; EC925=0.2270 μg/mL.
Ipilimumab inhibited the tumor growth of MC38 on huCTLA-4 mice. The result showed significant anti-tumor effects; with an tumor inhibition rate (TGI) of 99.3% at 0.88 mpk at D37.
Quick Database Links
Gene Symbol
CTLA-4 / CD152
UniProt
UniProt Details
− No UniProt data available
Documents Download
Datasheet
Product Information
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Protocol Information
FACS
Fluorescence-Activated Cell Sorting (FC, Flow cytometry)
ELISA
Enzyme-linked Immunosorbent Assay (EIA)
CTLA-4/CD152 Antibody (orb1806363)
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