HGFR/c-Met Antibody (MMAE)

SKU: orb1805476

Description

Anti-HGFR / c-Met Reference Antibodydy and Monomethyl auristatin E (MMAE) that has recently obtained the breakthrough therapy designation (BTD) for the treatment of patients with c-Met overexpression, advanced/metastatic wild-type (WT) epithelial growth factor receptor (EGFR) non-squamous non-small cell lung cancer (sqNSCLC) that progressed during or after platinum-based chemotherapy.

Images & Validation

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Item 1 of 3

Tested Applications	ELISA, FA, FACS, In vivo
Reactivity	Human

Key Properties

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Antibody Type	Recombinant Antibody
Clonality	Recombinant
Target	HGFR / c-Met
Source/Expression System	CHO
Molecular Weight	151.37 kDa
Purity	>95%
Purification	Protein A
Endotoxin	<0.001 EU/ug
Conjugation	MMAE

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	100 mM Proline/Acetic acid 20mM Arginine pH 5.0
Concentration	Batch dependent
Disclaimer	For research use only

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Anti-HGFR / c-Met Reference Antibody (telisotuzumab vedotin) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

The purity of Anti-HGFR / c-Met Reference Antibody (telisotuzumab vedotin)is more than 95% ;determined by SEC-HPLC.

Immobilized human cMet His at 2 μg/mL can bind Anti-HGFR / c-Met Reference Antibody (telisotuzumab vedotin);EC50=0.105μg/mL.

Quick Database Links

Gene Symbol

HGFR / c-Met

UniProt

P08581

UniProt Details

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No UniProt data available

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Protocol Information

FACS

Fluorescence-Activated Cell Sorting (FC, Flow cytometry)

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ELISA

Enzyme-linked Immunosorbent Assay (EIA)

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