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Description
Research Area
Cancer Biology
Images & Validation
−![Anti-PD-1 [5C4.B8 (Nivolumab)]](/images/pub/media/catalog/product/NewWebsite/35/orb1821655_1.png)
![Anti-PD-1 [5C4.B8 (Nivolumab)]](/images/pub/media/catalog/product/NewWebsite/35/orb1821655_2.png)
Item 1 of 2
| Tested Applications | Blocking, FC, IHC, SBR |
|---|---|
| Reactivity | Human, Monkey |
Key Properties
−| Host | Human |
|---|---|
| Clonality | Monoclonal |
| Isotype | Human IgG |
| Clone No. | 5C4.B8 (Nivolumab) |
| Immunogen | mAb PD1.5 was prepared by immunizing IgH and IgK knock-out transgenic mice possessing a human immunoglobulin (heavy chain) minilocus with recombinant human PD-1-Fc protein consisting of the extracellular domain of PD-1 (amino acids 1–167) and the Fc portion of human IgG1, and Chinese hamster ovary (CHO) cells expressing human PD-1. Nivolumab was generated by grafting the variable regions of PD1.5 onto human kappa and IgG4 constant regions containing an S228P mutation (prevents Fab arm exchange with endogenous IgG4 antibodies). |
| Target | PD-1 |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| Buffer/Preservatives | PBS with 0.02% Proclin 300. |
| Concentration | 1 mg/ml |
| Expiration Date | 12 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
−CD279; programmed death-1; programmed death 1 ; PD1; PD 1; Programmed cell death protein 1; hPD-1; hPD1; hPD 1; BMS-936558; MDX-1106;ONO-4538
Similar Products
−- Item 1 of 2
Anti-PD-1 [5C4.B8 (Nivolumab)] [orb1821656]
Blocking, FC, IHC, SBR
Human, Monkey
Human
Monoclonal
Unconjugated
0.2 mg
![Anti-PD-1 [5C4.B8 (Nivolumab)]](/images/pub/media/catalog/product/NewWebsite/35/orb1821656_1.png)
![Anti-PD-1 [5C4.B8 (Nivolumab)]](/images/pub/media/catalog/product/NewWebsite/35/orb1821656_2.png)
Quality Guarantee
Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].
Quick Database Links
Gene Symbol
PD-1
UniProt
UniProt Details
− No UniProt data available
Protocol Information
IHC
Immunohistochemistry
FC
Flow Cytometry
Available Sizes
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Free Secondary Antibody (20 ul)0/0
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Usually dispatched within 5-10 working days