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AOH1160

SKU: orb1309993

Description

AOH1160 is a small molecule PCNA inhibitor that disrupts DNA replication, leading to cell cycle arrest and apoptosis. It is utilized in cancer research to study replication stress and has shown efficacy in both cellular and animal models of various malignancies.

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

CAS Number2089314-57-6
MW396.44
Purity99.52% (May vary between batches)
FormulaC25H20N2O3
SMILESC(NCC(NC1=C(OC2=CC=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
TargetApoptosis,DNA/RNA Synthesis
SolubilityDMSO:45 mg/mL (113.51 mM)

Bioactivity

Target IC50
PCNA:
In Vitro
AOH1160 selectively kills many types of cancer cells with mean GI50 of 330 nM and does not cause toxicity to nonmalignant cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DNASynthesis, DNA Synthesis, DNA replication, Apoptosis, AOH 1160, AOH1160, AOH-1160, PCNA, N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide, RNA Synthesis, RNASynthesis
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

AOH1160 (orb1309993)

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Available Sizes

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2 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
5 mg
¥ 1,170.00
10 mg
¥ 1,430.00
25 mg
¥ 2,080.00
50 mg
¥ 3,250.00
DispatchUsually dispatched within 3-5 working days
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