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AOH1996

SKU: orb1819088

Description

AOH1996 is an orally bioavailable PCNA-targeting ligand that disrupts transcription-replication conflicts. It stabilizes PCNA-RNA polymerase II interactions, inducing proteasomal degradation of RPB1, DNA damage, and apoptosis. This molecule shows synergistic activity with genotoxic agents in preclinical cancer models, providing a research tool for studying replication stress and combination therapies.

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

CAS Number2089314-64-5
MW426.46
Purity99.62%
FormulaC26H22N2O4
SMILESC(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
TargetDNA,Apoptosis
SolubilityDMSO:250 mg/mL (586.22 mM)

Bioactivity

Target IC50
PDAC cells:0.72 μM|KRAS (G12D):0.93 μM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DNA, AOH 1996, AOH1996, AOH-1996, apoptosis, PCNA

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Key Properties

No computed properties available.

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Protocol Information

AOH1996 (orb1819088)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,300.00
5 mg
¥ 2,470.00
10 mg
¥ 3,510.00
25 mg
¥ 6,630.00
50 mg
¥ 9,620.00
100 mg
¥ 13,390.00
500 mg
¥ 26,130.00
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