Apraclonidine hydrochloride

SKU: orb1705101

Description

Apraclonidine hydrochloride is a selective α2-adrenergic agonist used in ophthalmic research for lowering intraocular pressure. It is applied in studies of glaucoma therapy, serving as a pharmacological tool in both in vivo animal models and in vitro receptor binding assays.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	73218-79-8
MW	281.57
Purity	99.74%
Formula	C₉H₁₁Cl₃N₄
SMILES	Cl.Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1
Target	Adrenergic Receptor
Solubility	H2O:11.2 mg/mL (39.78 mM);DMSO:112.5 mg/mL (399.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.21 mM)

Bioactivity

−

In Vivo	Apraclonidine hydrochloride elevats intraocular pressure as well as glaucoma. Apraclonidine reduces aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery. Apraclonidine (1.15%) causes a 98% inhibition of PGE2-induced aqueous flare elevationy. Read more...
In Vitro	Apraclonidine hydrochloride penetrates the cornea and blood-brain barrier to a lesser extent.

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

P-aminoclonidine, Iopidine, Apraclonidina, Apraclonidine HCl, Apraclonidine Hydrochloride, Apraclonidinum, 4-Aminoclonidine, ALO 2145, ALO2145, ALO-2145, Adrenergic Receptor, AdrenergicReceptor, α2-adrenoceptor

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

51763 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols