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Apraclonidine hydrochloride

SKU: orb1705101

Description

Apraclonidine hydrochloride is a selective α2-adrenergic agonist used in ophthalmic research for lowering intraocular pressure. It is applied in studies of glaucoma therapy, serving as a pharmacological tool in both in vivo animal models and in vitro receptor binding assays.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number73218-79-8
MW281.57
Purity98.01% (May vary between batches)
FormulaC9H11Cl3N4
SMILESCl.Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1
TargetAdrenergic Receptor
SolubilityH2O:11.2 mg/mL (39.78 mM);DMSO:112.5 mg/mL (399.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.21 mM)

Bioactivity

In Vivo
Apraclonidine hydrochloride elevats intraocular pressure as well as glaucoma. Apraclonidine reduces aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery. Apraclonidine (1.15%) causes a 98% inhibition of PGE2-induced aqueous flare elevationy.
In Vitro
Apraclonidine hydrochloride penetrates the cornea and blood-brain barrier to a lesser extent.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

P-aminoclonidine, Iopidine, Apraclonidina, Apraclonidine HCl, Apraclonidine Hydrochloride, Apraclonidinum, 4-Aminoclonidine, ALO 2145, ALO2145, ALO-2145, Adrenergic Receptor, AdrenergicReceptor, α2-adrenoceptor
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 90.00
25 mg
$ 120.00
50 mg
$ 160.00
100 mg
$ 220.00
200 mg
$ 290.00
DispatchUsually dispatched within 3-5 working days
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