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APY29

SKU: orb1303952

Description

APY29

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1216665-49-4
MW332.36
Purity96.51% (May vary between batches)
FormulaC17H16N8
SMILESC1CC1c1cc(Nc2ccnc(Nc3ccc4nc[nH]c4c3)n2)n[nH]1
TargetIRE1
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.04 mM);DMSO:12.5 mg/mL (37.61 mM);H2O:< 1 mg/mL (insoluble)

Bioactivity

Target IC50
IRE1α:280 nM
In Vitro
APY29 selectively influences IRE1α by divergently modulating its RNase activity and oligomerization state through the same binding site, showing opposing effects on RNase activity. Additionally, APY29 has a dose-dependent, contrasting impact on ER stress-induced activation of the endogenous IRE1α RNase .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

APY 29, APY29, APY-29, Inhibitor, Inositol requiring enzyme 1, IRE1, IRE1α, inhibit

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    >98% (HPLC)

    1216665-49-4

    332.36

    C17H16N8

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 360.00
100 mg
$ 620.00
500 mg
$ 1,230.00
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