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AR-M 1896 Acetate

SKU: orb1306260

Description

AR-M 1896 Acetate is a potent and selective agonist for the galanin receptor subtype 2 (GalR2). This compound is a valuable research tool for investigating GalR2 signaling in vitro and exploring its potential roles in mood regulation, neuroprotection, and pain processing in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

MW1196.35
Purity95.32% (May vary between batches)
FormulaC56H85N13O16
SMILESCC(O)=O.CC(C)C[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC(CNC([C@H](C)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CC2=CNC3=C2C=CC=C3)N)=O)=O)=O)=O)=O)=O)=O)=O)=O
TargetNeuropeptide Y Receptor
SolubilityDMSO:55 mg/mL (45.97 mM)

Bioactivity

Target IC50
GalR2:1.76 nM|GalR1 (human):879 Nm
In Vivo
In normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. The same effect is seen with equimolar doses of AR-M1896 or AR-M961 (an agonist both at GalR1 and GalR2 receptors). In allodynic Bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high AR-M961dose, whereas no effect was observed in the control or AR-M1896 group. No effect of either compounds was observed in nonallodynic Bennett model rats.
In Vitro
Removal of the glycine residue in position 1 resulted in AR-M1896 with almost unchanged GalR2 affinity and functional activity, and 500-fold selectivity for GalR2-Rs over GalR1-Rs.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

367518-31-8, 367518-31-8 Free base, ARM 1896 Acetate, AR-M 1896 Acetate, AR-M 1896 Acetate (367518-31-8 Free base), AR-M1896 Acetate, AR-M-1896 Acetate, AR M 1896 Acetate, GAL2, NeuropeptideYReceptor, Neuropeptide Y Receptor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 380.00
5 mg
$ 720.00
10 mg
$ 960.00
25 mg
$ 1,390.00
1 ml x 10 mM (in DMSO)
$ 1,430.00
50 mg
$ 1,820.00
100 mg
$ 2,420.00
DispatchUsually dispatched within 3-5 working days
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