Arctiin

SKU: orb1305048

Description

Arctiin, also known as Arctigenin-4-glucoside, is a small molecule agonist of the adiponectin receptor 1 (AdipoR1). It has demonstrated anti-cancer properties in research, with studies indicating its activity in both in vitro cell-based assays and in vivo animal models of tumor growth.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	20362-31-6
MW	534.55
Purity	99.81% (May vary between batches)
Formula	C₂₇H₃₄O₁₁
SMILES	COc1ccc(C[C@H]2COC(=O)[C@@H]2Cc2ccc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(OC)c2)cc1OC
Target	Adiponectin Receptor
Solubility	Ethanol:93 mg/mL (173.98 mM);H2O:37 mg/mL (69.22 mM);DMSO:50 mg/mL (93.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.74 mM)

Bioactivity

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In Vivo	Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice.
In Vitro	Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer.
Cell Research	HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.(Only for Reference)

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NSC 315527, NSC315527, NSC-315527, Arctigenin-4-glucoside, Arctii, Arctiin, Adiponectin receptor, Adiponectinreceptor

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Compound Identifiers

PubChem CID

100528 ↗

Key Properties

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No computed properties available.

Protocol Information

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Purity:	>98% (HPLC)
CAS Number:	20362-31-6
MW:	534.55
Formula:	C₂₇H₃₄O₁₁

Arctiin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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