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Arecoline

SKU: orb1740527

Description

Arecoline is a natural alkaloid from the areca nut, acting as a potent nicotinic and partial muscarinic acetylcholine receptor agonist. It is utilized in research for its anti-anxiety and anti-parasitic properties, as well as in studies modeling Alzheimer's disease and oxidative stress in both in vitro and in vivo experimental systems.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number63-75-2
MW155.19
Purity99.28%
FormulaC8H13NO2
SMILESC(OC)(=O)C=1CN(C)CCC1
TargetAChR,Reactive Oxygen Species
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.89 mM);DMSO:55 mg/mL (354.4 mM)

Bioactivity

In Vitro
Arecoline induces reactive oxygen species generation and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting p21/Cip1 expression. It also upregulates stress-responsive genes such as hemeoxygenase-1, ferritin light chain, glucose-6-phosphate dehydrogenase, glutamate-cysteine ligase catalytic subunit, and glutathione reductase. At higher concentrations, arecoline causes epithelial cell death due to oxidative trauma without triggering apoptosis.

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Reactive Oxygen Species, ReactiveOxygenSpecies, AChR, Nicotinic Receptor

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Key Properties

No computed properties available.

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Arecoline (orb1740527)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 ml x 10 mM (in DMSO)
¥ 910.00
100 mg
¥ 1,040.00
500 mg
¥ 1,820.00
1 g
¥ 2,470.00
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