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ARN-6039

SKU: orb1702534

Description

ARN-6039 is an orally bioavailable RORγ inverse agonist developed for autoimmune neuroinflammatory demyelinating disease research. It inhibits RORγ activity, demonstrated by an IC50 of 360 nM in a cellular reporter assay and 220 nM in suppressing IL-17 release from primary CD4+ T cells. This tool compound is used in vitro and in vivo to study Th17 cell biology and autoimmune disease mechanisms.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1675206-11-7
MW406.40
FormulaC21H21F3N2O3
SMILESCOc1cc2C(=O)C(Cc3ncccc3C(F)(F)F)Cc2cc1N1CCOCC1
TargetOthers,ROR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

ARN-6039 (orb1702534)

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