ARRY 520 hydrochloride

SKU: orb1296056

Description

ARRY-520 hydrochloride is a potent and selective kinesin spindle protein (KSP/Eg5) inhibitor. It exhibits anti-proliferative activity by inducing mitotic arrest and apoptosis in cancer cells, and has been investigated in preclinical in vitro and in vivo studies for oncology research, particularly in hematological malignancies.

Research Area

Cell Biology, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	1385020-40-5
MW	456.94
Purity	99.62% (May vary between batches)
Formula	C₂₀H₂₃ClF₂N₄O₂S
SMILES	O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.[H]Cl
Target	Apoptosis,Kinesin,KSP
Solubility	DMSO:50 mg/mL (109.42 mM)

Bioactivity

−

In Vivo

ARRY 520 has anti-tumor activitiy in vivo. ARRY 520 induced a decrease in tumor kinetics in a dose-dependent manner in female nude mice, EOC mice xenograft model.

In Vitro

ARRY 520 causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells. ARRY 520 induces mitotic arrest in multiple cell lines and exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors.ARRY 520 induces apoptosis in a dose-dependent manner in HeLa cells. ARRY 520 potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells. ARRY 520 is able to induce caspase-2 activation. ARRY 520 is cytotoxic in Type II EOC cells.

Storage & Handling

−

Storage	Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

KSP, ARRY 520 Hydrochloride, ARRY 520 hydrochloride, ARRY520 Hydrochloride, ARRY-520 Hydrochloride

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

72942033 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols