Asciminib hydrochloride

SKU: orb1686815

Description

Asciminib hydrochloride (Scemblix) is a STAMP inhibitor that selectively targets the ABL myristoyl pocket. It is used in research for Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), modulating oncogenic signaling through allosteric binding, as demonstrated in in vitro and in vivo studies.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2119669-71-3
MW	486.3
Purity	99.91% (May vary between batches)
Formula	C₂₀H₁₉Cl₂F₂N₅O₃
SMILES	C(NC1=CC=C(OC(Cl)(F)F)C=C1)(=O)C2=CC(=C(N=C2)N3CC[C@@H](O)C3)C=4C=CNN4.Cl
Target	Bcr-Abl
Solubility	DMSO:80 mg/mL (164.51 mM);H2O:< 1 mg/mL (insoluble)

Bioactivity

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In Vivo

In animal experiments conducted on young mice (P6-P7 days old), a combined treatment of Asciminib hydrochloride (0.1–0.5 mg/kg) and cyclophosphamide (100 mg/kg) was administered via intraperitoneal injection to evaluate its protective effects on ovarian reserve. The experimental results demonstrated that Asciminib hydrochloride at a dose of 0.25 mg/kg significantly alleviated Cy-induced DNA damage stress signaling, manifested by the inhibition of TAp63 protein modification, reduced expression of DNA damage response markers such as γH2AX and phosphorylated DNA-PK, and decreased activation of cleaved PARP in oocytes. Additionally, Asciminib hydrochloride suppressed Akt phosphorylation in follicular reserve cells, indicating its regulatory role in Cy-triggered excessive follicular activation [2.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ABL001 hydrochloride, ABL-001 hydrochloride

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Compound Identifiers

PubChem CID

133082086 ↗

Key Properties

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No computed properties available.

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