Asciminib hydrochloride

SKU: orb1686815

Description

Asciminib hydrochloride (Scemblix) is a STAMP inhibitor that selectively targets the ABL myristoyl pocket. It is used in research for Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML), modulating oncogenic signaling through allosteric binding, as demonstrated in in vitro and in vivo studies.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2119669-71-3
MW	486.3
Formula	C₂₀H₁₉Cl₂F₂N₅O₃
SMILES	Cl.O[C@@H]1CCN(C1)c1ncc(cc1-c1cc[nH]n1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1
Target	Others
Solubility	DMSO:80 mg/mL (164.51 mM);H2O:< 1 mg/mL (insoluble)

Bioactivity

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In Vivo

In animal experiments conducted on young mice (P6-P7 days old), a combined treatment of Asciminib hydrochloride (0.1–0.5 mg/kg) and cyclophosphamide (100 mg/kg) was administered via intraperitoneal injection to evaluate its protective effects on ovarian reserve. The experimental results demonstrated that Asciminib hydrochloride at a dose of 0.25 mg/kg significantly alleviated Cy-induced DNA damage stress signaling, manifested by the inhibition of TAp63 protein modification, reduced expression of DNA damage response markers such as γH2AX and phosphorylated DNA-PK, and decreased activation of cleaved PARP in oocytes. Additionally, Asciminib hydrochloride suppressed Akt phosphorylation in follicular reserve cells, indicating its regulatory role in Cy-triggered excessive follicular activation [2.

In Vitro

Pretreatment with Asciminib hydrochloride (0.5 μM) for 1 hour did not interfere with the DNA damage response signaling induced by 4-OH-Cy in MCF7 cells. Compared to the 4-OH-Cy treatment alone group, the Asciminib hydrochloride pretreatment group showed no significant differences in the expression levels of DNA damage marker proteins such as phosphorylated ATM (p-ATM), γH2AX, and phosphorylated p53 . Parazacco spilurus subsp. spilurus .

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ABL001 hydrochloride, ABL-001 hydrochloride

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Compound Identifiers

PubChem CID

133082086 ↗

Key Properties

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No computed properties available.

Protocol Information

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Purity:	>98% (HPLC)
CAS Number:	2119669-71-3
MW:	486.3
Formula:	C₂₀H₁₉Cl₂F₂N₅O₃

Asciminib hydrochloride

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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