Ascrinvacumab Antibody

SKU: orb1980585

Description

Ascrinvacumab (PF-03446962) is a humanized IgG2 monoclonal antibody targeting ALK-1 with high affinity (Kd = 7 nM). It functions as an inhibitor of TGF-β signaling and is utilized in research applications for hepatocellular carcinoma (HCC), including in vitro and in vivo experimental models.

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1463459-96-2
MW	150 kDa
Purity	98.18% (SEC-HPLC)
Target	TGF-beta/Smad,ALK

Bioactivity

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Target IC50	ALK1 (human):7 nM(Kd)
In Vivo	In a mouse xenograft tumor model, the combination of Ascrinvacumab with bevacizumab (anti-VEGF) reduces human vascular density and enhances the anti-tumor efficacy. Read more...
In Vitro	Ascrinvacumab binds to human ALK1 with a Kd value of 7 nM. In a 30-minute treatment, Ascrinvacumab blocks the response induced by BMP9 and FCS, alleviating BMP9-induced Smad1 phosphorylation intensity and duration. At concentrations ranging from 0.01 to 10 μg/mL for 2 hours, Ascrinvacumab inhibits the binding of BMP9 to ALK1. At 40 μg/mL for 2 hours, Ascrinvacumab effectively inhibits endothelial sprouting in human umbilical vein endothelial cells (HUVECs). Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Ascrinvacumab, ALK1, TGFbeta/Smad, TGF-beta/Smad, TGF-beta, TGF-β/Smad, TGFβ, TGF-b/Smad, TGFbeta, TGFb, Smad, PF03446962, PF-03446962, PF 03446962

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Gene Symbol

TGF-beta/Smad,ALK

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