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ASM-024

SKU: orb1701165

Description

ASM-024 is a synthetic piperazine and potent nicotinic receptor agonist that induces smooth muscle relaxation via β2-adrenergic receptor signaling pathways. This compound demonstrates anti-inflammatory activity and is a research tool for investigating potential therapeutics for asthma and chronic obstructive pulmonary disease (COPD) in experimental models.

Research Area

Neuroscience

Images & Validation

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ASM-024

Key Properties

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CAS Number1609534-88-4
MW233.37
Purity99.58% (May vary between batches)
FormulaC15H25N2
SMILESC(C)[N+]1(CC)CCN(CCC1)C2=CC=CC=C2
TargetAChR
SolubilityDMSO:2.34 mg/mL (10.03 mM)

Bioactivity

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In Vivo
ASM-024 increased in vitro relaxation response to maximally effective concentration of short—acting beta-2 agonists in dog and human bronchi. ASM-024 induces smooth muscle relaxation of β2-AR desensitized tracheas.
In Vitro
Incubation of HBSMC cells with ASM-024 did not induce significant production of cAMP compared to salbutamol or formoterol treated cells. Fifteen minutes of incubation of hBSMC with ASM-024 alone had no effect on [Ca2+]i. However, a 10 minute pre-treatment with ASM-024 decreased [Ca2+]i rise in cells challenged with 10-6 M histamine or methacholine.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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ASM 024, ASM024, ASM-024, ASM-024 cation, Nicotinic Receptor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
58063720 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 200.00
2 mg
$ 270.00
1 ml x 10 mM (in DMSO)
$ 360.00
5 mg
$ 430.00
10 mg
$ 590.00
25 mg
$ 870.00
DispatchUsually dispatched within 3-5 working days
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