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Asundexian

SKU: orb1691292

Description

Asundexian (BAY-2433334) is a potent, oral, and reversible active-site inhibitor of coagulation factor XIa (FXIa), exhibiting an IC₅₀ of 1 nM against human FXIa. Its research applications include the study of thrombotic conditions such as ischemic stroke, supported by investigations into its antithrombotic efficacy in preclinical in vivo models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2064121-65-7
MW592.93
Purity99.90%
FormulaC26H21ClF4N6O4
SMILESCC[C@@H](C(=O)Nc1ccc(C(N)=O)c(F)c1)n1cc(OC)c(cc1=O)-c1cc(Cl)ccc1-n1cc(nn1)C(F)(F)F
TargetFactor Xa
SolubilityDMSO:150 mg/mL (252.98 mM)

Bioactivity

Target IC50
FXIa (human):1 nM
In Vivo
Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Asundexian, BAY2433334, BAY-2433334, BAY 2433334, FactorXa, Factor Xa
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Asundexian (orb1691292)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
¥ 2,990.00
5 mg
¥ 6,760.00
1 ml x 10 mM (in DMSO)
¥ 7,410.00
10 mg
¥ 10,790.00
25 mg
¥ 20,410.00
50 mg
¥ 32,630.00
DispatchUsually dispatched within 5-10 working days
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