AT2 receptor agonist C21

SKU: orb1707632

Description

Buloxibutid (C21) is a selective AT2 receptor agonist with high affinity (Ki = 0.4 nM) and significant selectivity over the AT1 receptor. It is a valuable research tool for investigating the renin-angiotensin system in models of cardiovascular and renal disease, fibrosis, and inflammation, both in vitro and in vivo.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	477775-14-7
MW	475.62
Purity	98.58%
Formula	C₂₃H₂₉N₃O₄S₂
SMILES	CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1
Target	RAAS
Solubility	DMSO:22.5 mg/mL (47.31 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.21 mM)

Bioactivity

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Target IC50	AT1:>10 μM(ki)\|AT2:0.4 nM(ki)
In Vivo	Buloxibutid, with an oral bioavailability of 20-30% and a 4-hour half-life in rats, induces neurite cell outgrowth, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers mean arterial blood pressure in anesthetized, spontaneously hypertensive rats. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AT2 receptor agonist C21, AT2, AT2 receptor, AT1, Buloxibutid

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Compound Identifiers

PubChem CID

9804984 ↗

Key Properties

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No computed properties available.

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