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AU-15330

SKU: orb1690940

Description

AU-15330 is a PROTAC molecule that induces the degradation of SMARCA4, SMARCA2, and PBRM1. It demonstrates selective cytotoxicity in H3.3K27M-mutant cells in vitro, making it a candidate for research in oncology, particularly for studying chromatin remodeling complexes in diffuse midline glioma models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2380274-50-8
MW755.93
Purity99.62%
FormulaC39H49N9O5S
SMILESC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CN1CCN(CC1)c1cc(nnc1N)-c1ccccc1O)C(C)(C)C)c1ccc(cc1)-c1scnc1C
TargetEpigenetic Reader Domain,PROTACs
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (6.61 mM);DMSO:252.5 mg/mL (334.03 mM)

Bioactivity

In Vivo
METHODS: AU-15330 (60 mg kg, i.v.) was administered to mice bearing VCaP and C4-2B castration-resistant tumor models, 3 days per week. RESULTS AU-15330 inhibited tumor growth in mice bearing VCaP and C4-2B castration-resistant tumor models without significant toxicity.
In Vitro
METHODS: PCa cells (LNCaP, VCaP, 22RV1, and LAPC4) were treated with different concentrations of AU-15330 (0.1, 1 μM). RESULTS AU-15330 attenuated the growth of these cells and induced apoptotic cell death, while having no antiproliferative effect on benign or non-neoplastic prostate cells.

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AU15330, AU-15330, AU 15330, EpigeneticReaderDomain, Epigenetic Reader Domain, PROTAC

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Quality Guarantee

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Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

AU-15330 (orb1690940)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

1 mg
¥ 2,340.00
5 mg
¥ 5,070.00
10 mg
¥ 7,540.00
25 mg
¥ 11,830.00
50 mg
¥ 15,860.00
100 mg
¥ 21,190.00
DispatchUsually dispatched within 3-5 working days
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