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Avatrombopag

SKU: orb1299838

Description

Avatrombopag is a small molecule thrombopoietin receptor agonist that stimulates megakaryocyte growth and platelet production. It is widely used in research for studying thrombocytopenia, with applications in both in vitro cellular assays and in vivo animal models to investigate hematopoiesis and platelet disorders.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number570406-98-3
MW649.65
Purity99.41% (May vary between batches)
FormulaC29H34Cl2N6O3S2
SMILESOC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(-c2cc(Cl)cs2)c(s1)N1CCN(CC1)C1CCCCC1
TargetThrombin|||Thrombopoietin Receptor
SolubilityDMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
TPO receptor:3.3 nM (EC50)
In Vivo
Avatrombopag is treatment of thrombocytopenia in patients with CLD who are scheduled to undergo a procedure.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

E5501, E-5501, E 5501, Avatrombopag, AKR 501, AKR501, AKR-501, mimic, NOD/SCID, inhibit, megakaryocytes, megakaryocytopoiesis, Inhibitor, YM 477, YM477, YM-477, proliferation, phosphorylation, Thrombopoietin Receptor, ThrombopoietinReceptor, TPO

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
2 mg
$ 130.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 400.00
50 mg
$ 610.00
100 mg
$ 830.00
500 mg
$ 1,830.00
DispatchUsually dispatched within 3-5 working days
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