Aviptadil Acetate

SKU: orb1296793

Description

Aviptadil Acetate, the acetate salt of Vasoactive Intestinal Peptide (VIP), is a research compound that promotes pulmonary vasodilation while suppressing vascular smooth muscle cell proliferation and platelet aggregation. Its applications include experimental studies in pulmonary arterial hypertension (PAH), pulmonary fibrosis, and respiratory distress, such as that associated with SARS-CoV-2 infection.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1444827-29-5
MW	3385.9
Purity	>99.99% (May vary between batches)
Formula	C₁₄₇H₂₃₈N₄₄O₄₂S.C₂H₄O₂
SMILES	OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC(N)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCSC)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@@H](N)CC2=CN=CN2)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Target	RAAS,SARS-CoV
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (0.97 mM);DMSO:95 mg/mL (28.06 mM)

Bioactivity

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In Vivo	Inhaled vasoactive intestinal peptide(Aviptadil acetate ) as a local therapy to reduce the alveolar inflammation found in patients with immune checkpoint inhibitor pneumonitis. Read more...
In Vitro	Aviptadil acetate inhibits the basal proliferation of pulmonary arterial smooth muscle cells (PASMC) and the mobilization of intracellular free calcium concentration in these cells in a dose-dependent manner. Read more...

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Vasoactive Intestinal Peptide Acetate, Vasoactive Intestinal Peptide acetate salt, Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine), Sarcoid, Sarcoidosis, SARS coronavirus, SARSCoV, SARS-CoV-2, SARS-CoV, Respiratory Distress Syndrome, Respiratory Failure, Pulmonary Fibrosis, inhibit, Lung Injury, Inhibitor, Corona Virus, Bronchospasm, Aviptadil, Aviptadil Acetate, ARDS, ACE, ALI

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

91820620 ↗

Key Properties

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No computed properties available.

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