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AZD-0156

SKU: orb1225871

Description

AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM inhibitor; exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.Solid Tumors Phase 1 Clinical(In Vitro):AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.

Images & Validation

Key Properties

CAS Number1821428-35-6
MW461.556
Purity>98% (HPLC)
FormulaC26H31N5O3
SMILESO=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3
TargetATM/ATR
SolubilityDMSO: 6.2 mg/mL (Need ultrasonic and warming)

Bioactivity

In Vitro
AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AZD0156 | AZD 0156

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  • AZD0156 [orb1300483]

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    C26H31N5O3

    500 mg, 25 mg, 100 mg, 50 mg, 2 mg, 5 mg, 10 mg, 1 mg
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AZD-0156 (orb1225871)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,170.00
5 mg
¥ 1,690.00
10 mg
¥ 2,340.00
25 mg
¥ 3,640.00
50 mg
¥ 5,850.00
100 mg
¥ 9,360.00
500 mg
¥ 19,500.00